St. Mary's College is built on an acre of Society owned Land and Building at Yousufguda, a prominent business place on the North West side of Hyderabad city. The Campus at Yousufguda houses in all about 1800 students for both the Intermediate and Degree courses. The location is also very near to the up market localities of twin cities viz., Banjara Hills, Jubilee Hills, Filmnagar, Madhapur etc. Major sections of the people here belong to the middle class or upper middle class group.
In a short period of three years, the Yousufguda College reputation rose to being recognized as one of the top 3 Co Educational colleges of the City. The decade old institution has churned out eminent sports persons like Sania Mirza and Ashwini Ponnappa, gold medallist at the Common Wealth Games, New Delhi. The college was also home for eminent political personalities, who are presently Members of Parliament and the A.P. State Legislative Assembly.
The strength of the college increased from a modest 70 students in 2002 to 1800 presently.